WebAs such, these antigens are designated cancer/testis antigens (CT antigens). Since the early 1980s, about 70 families of CT antigens have been identified with over 140 … WebCancer/testis antigens (CTAs) are considered ideal targets for cancer treatment due to their high immunogenic, restricted expression in germ cells and malignancies. 7–9 …
Clinical significance of cancer/testis antigens expression in patients ...
WebJun 9, 1998 · CT antigens share the following characteristics: ( i) predominant mRNA expression in testis, but generally not in other normal somatic tissues, ( ii) gene activation and mRNA expression in a wide range of human tumor types, ( iii) existence of multigene families, and ( iv) with one exception, localization of coding genes to chromosome X. Six … WebMar 15, 2024 · Cancer/testis (CT) antigens match these criteria for an ideal target, as CT antigens are tumor antigens that are identified with a normal expression and restricted … tscc 2871
Cancer-Testis (CT) Antigens - Holland-Frei Cancer Medicine - NCBI Boo…
WebOct 11, 2009 · Cancer/testis (CT) antigens are protein antigens with normal expression restricted to adult testicular germ cells, and yet are aberrantly activated and expressed … WebJan 1, 2006 · Abstract. CT10/MAGE-C2 is a recently identified antigen that, typically of cancer/testis (CT) antigens, can be found in various malignant tumors and in normal … Cancer/testis (CT) antigens are a group of proteins united by their importance in development and in cancer immunotherapy. In general, expression of these proteins is restricted to male germ cells in the adult animal. However, in cancer these developmental antigens are often re-expressed and can serve as a … See more With the development of tumor-associated antigens (TAA), the first clone of a human tumor antigen, melanoma antigen-1 (MAGE-1) was reported in 1990s, which elicited an autologous cytotoxic T-lymphocyte (CTL) … See more Germ cells share some features with cancers. The motile and penetrating features and colonization of primitive germ cells resemble the … See more Immunogenicity In normal tissues, CT antigens are exclusively expressed in testis, making it no access to the immune system. Besides, the existence of blood-testis barrier and the lack of human leukocyte antigen (HLA) class I expression … See more CT antigens can be divided by whether they are encoded on the X chromosome (X-CT antigens genes) or not (non-X-CT antigens genes). It … See more The expression of CT antigens genes are exclusively regulated by epigenetic events both in normal and cancer tissues, while DNA methylation and histone post-translational modification remain the most widely characterized epigenetic factors here. See more tscc 2885